
Zepbound holds the top spot on the MeAgain Index as the most used GLP-1 on the platform and as Lilly pushed new research against Novo's newest Wegovy HD, saying Zepbound's top dose was associated with 4.5 percentage points more weight loss than Wegovy HD. A Lilly-funded study also found that adults 55+ on Zepbound had lower health care costs than similar adults who were not. Insurers may well take note of this as they decide what to cover heading into 2027. Zepbound growth also remained strong, as Lilly noted US sales rose 48% in the third quarter.
A MeAgain survey in August revealed another lead for Zepbound. Its users were the most likely to report that it is working better than they had hoped, far ahead of anyone on a non-Lilly medicine. Out of over 10,000 members, 19% of those on Zepbound said so, compared with 12% on Wegovy injections and only 8% on the Wegovy Pill.
Despite these survey results, Wegovy finally breaks into the top three meds on the MeAgain Index, moving up one place. A big change for Novo this quarter was Medicare's temporary GLP-1 Bridge, which began offering Wegovy to eligible seniors for $50 a month on July 1st, with the same coverage applying to the Wegovy Pill (which holds onto fifth).
Compounded tirzepatide slips one place to fourth. Things have not gotten any easier for compounded GLP-1s, with an appeals court upholding the end of the tirzepatide shortage in August. Even so, they still have a big following, and a Gallup survey published in July found that 18% of Americans taking a GLP-1 for weight loss use a compounded version. From what we see on the MeAgain platform, we would not be surprised if the real number is even higher than Gallup's estimate.















