MacroFactor dynamically adjusts your macros based on expenditure data. MeAgain adjusts your tracking around the GLP-1 experience — appetite suppression, dose titration, side effects, and medication levels. Same precision, different purpose.

Last updated March 2026
MacroFactor uses an adaptive TDEE algorithm to dynamically adjust your macro targets based on your actual expenditure data. MeAgain tracks the things MacroFactor's algorithm doesn't account for: GLP-1 injection schedules, dose titration, side effects, and medication level changes that shift your appetite and nutritional needs week to week. MacroFactor has algorithm-driven macro prescriptions MeAgain doesn't offer — MeAgain has the GLP-1 tools MacroFactor wasn't designed for.



| Feature | MeAgain | MacroFactor |
|---|---|---|
| Shot day checklist with prep steps | ||
| Injection tracking and site rotation | ||
| Estimated medication levels chart | ||
| Capybara home screen widget | ||
| Side effect tracking with severity slider | ||
| AI chat companion (Capy) | ||
| Zero markup GLP-1 medications | ||
| Photo food logging | ||
| Macro tracking | ||
| Weight trending | ||
| Barcode scanning | ||
| Progress charts | ||
| Adaptive TDEE algorithm | ||
| Coach-style macro prescription | ||
| Expenditure tracking |
MacroFactor's adaptive algorithm assumes your energy expenditure changes gradually and linearly. GLP-1 dose titration doesn't work that way — appetite suppression can shift dramatically when you move from 0.5mg to 1mg semaglutide, and side effects often peak in the first week of a new dose. MeAgain logs your current dose, titration date, and medication so you always have the injection context alongside your nutrition data.

MeAgain's shot day checklist walks you through prep steps on injection day. The injection site rotation map records where you last injected and suggests where to go next. The estimated medication levels chart visualizes your pharmacokinetic curve across the week — showing how your drug concentration changes between doses and how that correlates with appetite changes.

MeAgain tracks 6 default GLP-1 symptoms — nausea, fatigue, constipation, heartburn, food noise, suppressed appetite — plus custom symptoms with a severity slider (0–10) and date/time per entry. This structured log gives you a timeline that connects side effects to dose changes and titration milestones. MacroFactor has no side effect tracking.

The Capybara home screen widget puts your daily protein, fiber, water, and steps progress on your iPhone home screen — updated in real time with 9 mood states. Widget users have half the churn rate of non-widget users. Capy, MeAgain's AI chat companion, is personalized to your doses, side effects, and GLP-1 journey — not general macro coaching.

MacroFactor's core innovation is using your actual weight trend data to estimate your total daily energy expenditure (TDEE) and then adjusting your macro targets accordingly. This is genuinely useful for the general population — most people underestimate or overestimate their calorie needs, and algorithm-driven correction beats guessing. GLP-1 medication introduces variables the algorithm wasn't designed to handle.
Semaglutide and tirzepatide suppress appetite in ways that are non-linear and dose-dependent. When you titrate from a lower dose to a higher one, your caloric intake may drop significantly in the first week — not because your expenditure changed, but because the medication changed. An adaptive TDEE algorithm may interpret this as reduced expenditure and potentially lower your macro targets further — which is the opposite of what most GLP-1 subscribers need.
| Variable | MacroFactor | MeAgain |
|---|---|---|
| Calorie/macro targets | Algorithm-adjusted based on weight trend | User-set with GLP-1 protein/fiber/water emphasis |
| Appetite suppression tracking | Inferred from eating behavior | Directly logged as side effect (suppressed appetite) |
| Dose titration awareness | Not tracked | Injection log with dose, medication, date, and notes |
| Medication levels | Not tracked | 7-day pharmacokinetic curve chart |
| Side effect logging | Not available | Structured log with severity slider |
| Photo food logging | Not available | AI meal scan with macro breakdown |
MacroFactor's adaptive TDEE approach is genuinely valuable for tracking your true expenditure without lab testing. Some subscribers use MacroFactor for macro prescription and MeAgain for the GLP-1-specific tools — injection tracking, medication levels, side effects, and the Capybara widget.
This content is for informational purposes only and does not constitute medical advice. Always consult your healthcare provider about your GLP-1 medication and nutritional needs.
MacroFactor users who start GLP-1 often find the algorithm works against the medication experience — appetite suppression gets misread as reduced expenditure, dose titration isn't tracked, and there's no way to log side effects or medication levels. MeAgain was built for exactly the gap.
MeAgain is the all-in-one GLP-1 care partner — built for the daily experience of being on medication, with the shot day checklist, medication levels chart, and zero markup meds that an expenditure tracker was never designed to provide.

MeAgain is purpose-built for GLP-1 medication users, while MacroFactor is built around an adaptive TDEE algorithm for precise macro management. MeAgain adds injection tracking, a shot day checklist, estimated medication levels, side effect logging, and photo food logging that MacroFactor doesn't have. Both apps track macros, weight trends, barcode scanning, and progress charts.

Track the plan, dose, meals, and milestones in one place that actually keeps up with your day.