GLP-1 injection management

What is the best rotation schedule for GLP‑1 injection sites?

Alternate left/right abdomen and left/right thigh or arm weekly to minimize lumps and ensure even absorption. Avoid re‑using a spot within four weeks, and note any redness or firmness for your clinician. Some spots may see higher reduction in food noise than others, which is known in the community as your "sweet spot".

How can I prevent lumps, bruises, or itching at my GLP‑1 injection site?

Use a fresh needle, inject at 90 degrees into pinchable fat, let alcohol dry before inserting, and apply light pressure (not rubbing) after withdrawal. Cool compression can ease mild itching. Any persistent swelling needs medical review.

How long can my GLP‑1 pen stay unrefrigerated?

Most GLP-1 pens have limited room-temperature stability, ranging from 14 to 56 days depending on the brand. Semaglutide lasts the longest (up to 56 days), while tirzepatide is only stable for 21 days at ≤86°F (30°C). A good rule of thumb is to avoid keeping it at room temperature for longer than 21 days. Additionally, keep pens away from direct sunlight and never freeze; extreme temperatures degrade peptide potency.